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  Vaccines

 

  
Vaccines of varying efficacy and convenience exist for anthrax, smallpox, plague and tularemia, and vaccines are in development for other infectious agents that may be used in biological assaults. The major challenges in vaccine technology are to improve their safety, to develop vaccines against a variety of infectious agents (including new strains), to shorten the time needed to establish immunity (some vaccines require multiple boosters to be effective), and to be able to produce them in large quantities.

We are working to solve these problems with new vaccines based on improved delivery technologies and discoveries made through genetic research. Our researchers are using live attenuated vaccine vector technology to induce rapid protection. Applications include a third-generation anthrax vaccine. This strategy has the flexibility to address a number of different bioterrorism agents and can elicit a long-lasting immune response after a single oral dose. We are also working on fruits and vegetables genetically modified to contain vaccines. Such foods could protect large populations in a very short period of time.

Vaccines
Cell-based smallpox vaccines.
Tularemia vaccines.
Plague vaccines.
Rift Valley Fever vaccines.
Pandemic influenza vaccines.
C. botulinum/botulinum toxin vaccines.

 

 
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