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Our researchers are applying
genomics and proteomics technologies to discover weaknesses in viruses and
bacteria that can be targeted with a new generation of antibiotics and
antivirals. Such weaknesses include proteins or segments of RNA essential to an
infectious organism's survival or replication.
We are studying entailung rapid DNA analysis, followed by the rapid synthesis of
drugs that can bind, or disable, segments of DNA crucial to an infectious
organism's survival.
We are investigating those completed genome sequences for numerous infectious
agents, including the bacteria that cause malaria, stomach ulcers and food
poisoning, as well as organisms responsible for hospital-acquired infections,
cholera, pneumonia and chlamydia. Recently, the genome sequence was completed
for a potential biowarfare agent, the organism responsible for bubonic plague (Yersinia
pestis).
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Antivirals, especially against
smallpox and viral hemorrhagic fevers. |
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Antitoxins to B. anthracis and
C. botulinum. |
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Narrow-spectrum antibiotics,
especially for anthrax. |
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Passive immunotherapeutics,
including antibodies and soluble receptors. |
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Broadly reactive
antimicrobials. |
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