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The
industrialization of structural proteomics will increase the number of valuable
drug targets available. In the nearer term, we anticipate that this new
structure data will support the development of downstream activities,
particularly those directed at lead refinement or increasing the efficiency of
screening.
The recent determination that the human genome comprises only approximately
35,000 genes--not 60,000 to 100,000 as previously thought--has directed even
more attention to the role of proteins and, therefore, to the field of
structural proteomics.
One goal of this field is to reveal the structures of the key "functional" sites
of the giving human protein, which should make it much easier to develop highly
specific drugs, thus leading to more effective, and safer, pharmaceuticals.
Technological advances in protein structure determination, coupled with the
surge of genomic data, will lead to an exponential increase in the number of
known protein structures over the next few years. |