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Genomic and proteomic research
continues to produce a wealth of new targets for drug discovery. At the same
time, Pharmaceutical companies are amassing enourmous libraries of possible drug
compounds. The challenge facing the industry is to screen these millions of
compunds against each target. Drug screening is becoming a major bottleneck in
the drug discovery process and the pharmaceutical indutry is in great need of
high-throughput solutions.
High-throughput screening is a
process in which hundreds or thousands of compounds are simultaneously tested
for their ability to interact with a target. The screening system is called a
bioassay. Compounds that bind to the target on initial screens will then undergo
additional, more intensive screening, in order to assess their potential as
novel medicines for the treatment of disease. Typically, between 100,000 to two
million compounds will be screened to identify the handful that may constitute
lead candidates which move on through drug development.
Pharmacom is developing molecular profiling systems for screening the target
against libraries of chemical compounds to find those that will interact with
the target and that demonstrate the potential to become effective drugs.
The systems can be also designed
for screening very large numbers of drug candidates. These automated, flexible
systems offer biopharmaceutical companies significant savings in the time and
cost needed to discover new drugs. |