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Biomarkers
 Molecular Binding
Receptor and Ligand
RNA Interference
High-throughput Screening
High-content Screening
Biotechnology
Biodefense
Bioinformatics
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Molecular Binding |
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We are investigating the mechanism of
biomolecular binding and further develop the systems that enable
direct detection and monitoring of biomolecular binding events in
real time without labeling and often without purification of the
substances involved. Scientists are able to see binding events as
they occur and thereby generate more information about biological
interactions than from any other single alternative technology.
Hopefully, the system could provide the way to measure the speed of
binding events.
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Drug Discovery:
in the discovery, development and production of new
medicines/therapeutics. Access to fast, high quality,
characterization data of a compound in target specific and ADME
assays can have a significant impact on reducing time to market. |
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Life Science Research:
the study of biomolecular binding events in areas such as
proteomics, neuroscience, cancer research, developmental cell
biology, structural biology and immunology is essential for the
understanding of the fundamental mechanisms of living cells. The
systems we are developing will be applied to gaining this
knowledge helping to develop better ways to control and combat
diseases such as AIDS, Alzheimer's, and cancer. |
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Biodefense: The
systems will be used to provide superior accuracy, precision and
efficiency compared to conventional food and water analysis
techniques. |
Biomolecular binding occurs between
biomolecules that are biologically active. Detection and monitoring
of biomolecular binding events yields information to answer four key
questions:
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Question |
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Examples |
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How
much is binding? |
The concentration (quantity) of biologically active
molecule present in the sample can be quantified
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Monitoring of drug
concentration |
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Vitamin content in food |
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How
fast
is the binding event? |
The binding kinetics give information on the speed at
which interacting molecules bind to each other and break
apart |
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Monitoring signal transduction
during the study of communication between cells
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How
strong is the binding? |
The binding affinity gives information on the way
biological processes occur and are controlled
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Sample screening for drug
discovery
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How
specific is the binding? |
The binding specificity gives information on the ability
of a molecule to bind to another molecule to the
exclusion of others |
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Antibody production
for therapeutic or diagnostic purposes |
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Pharmacom Corporation
Copyright
1997-2007
