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DNA-interfaced Biosensors
RNA-interfaced Biosensors
Protein-interfaced Biosensors
Fatty Acid-interfaced Biosensors
Antibody-interfaced Biosensors
Cell-interfaced Biosensor
Bacterial-interfaced Biosensors
Enzyme-interfaced Biosensors
Chemical-interfaced Biosensors
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| Cell-interfaced Biosensors
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Cell-based biosensors can be
designed as portable devices that contain living biological cells that monitor
physiological changes induced by exposure to environmental perturbations such as
toxicants, pathogens or other agents. Methods of detecting physiological changes
include extracellular electrical recordings, optical measurements, and, in the
future, functional genomics and proteomics. Several technical developments are
occurring that will increase the feasibility of cell-based biosensors for field
applications; these developments include stem cell and 3D culture technologies.
Possible scenarios for the use of cell-based biosensors include broad-range
detectors of unknown threat agents and functional assessment of identified
agents. The following is an example of cell-based biosensors: Immobilizing the bacterium Acetobacter xylinium on an oxygen electrode offers the possibility of measuring ethanol in a medium. The measurement takes advantage of the respiratory activity of the bacterium. The immobilized bacterium behind the membrane metabolizes the ethanol with oxygen to acidic acid and water. This leads to an oxygen decrease in the biocatalytic layer which can then be measured by an electrode.
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Pharmacom Corporation
Copyright
1997-2007
